期刊
CLINICA CHIMICA ACTA
卷 445, 期 -, 页码 85-90出版社
ELSEVIER
DOI: 10.1016/j.cca.2015.03.017
关键词
Liver-type fatty acid-binding protein; Fatty acid; Acute kidney injury; Chronic kidney disease
资金
- National Basic Research Program of China 973 Program [2012CB517600, 2012CB517602]
- HongKong, Macao and Taiwan Science & Technology Cooperation Program of China [2014DFT30090]
- National Natural Science Foundation of China [81102700, 81373865, 81370794]
- National Key Technology RD Program [2011BAI10B08]
- Science and Technology Commission of Shanghai Municipality, China [12401906400, 13401906100, 14140903200]
- Shanghai Health Bureau [ZYSNXD012-RC-ZXY017]
Human liver-type fatty acid-binding protein (hL-FABP), which is found in both the normal and the diseased human kidney, has been observed to bind free fatty acids. Recently, the predictive and prognostic value of L-FABP in kidney diseases has attracted considerable attention. Numerous studies have demonstrated that L-FABP is a promising biomarker of several kidney diseases, and it has also been shown to attenuate renal injury. We performed a literature review regarding the ability of L-FABP to identify patients at risk of developing kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD) and to protect the kidneys in the course of kidney disease. (C) 2015 Elsevier B.V. All rights reserved.
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