期刊
CLINICA CHIMICA ACTA
卷 439, 期 -, 页码 178-184出版社
ELSEVIER
DOI: 10.1016/j.cca.2014.10.007
关键词
Zinc; Selenium; Toxic elements; Different types of cancer; Atomic absorption spectrophotometer
Background: It was investigated that carcinogenic processes are linked with the imbalances of essential trace and toxic elements in body fluid and tissues of human. In this study, the relationship between carcinogenic elements, arsenic (As), cadmium (Cd), and nickel (Ni), and anti-carcinogenic elements, selenium (Se) and zinc (Zn), in the scalp hair of different female cancer patients (breast, cervix, mouth and ovarian) was studied. Methods: The scalp hair samples were collected from cancer patients and referent female subjects of the same age group and socioeconomic status. The scalp hair samples were oxidized by 65% nitric acid and 30% hydrogen peroxide by microwave oven and analyzed by atomic absorption spectrometry. The validity and accuracy of the methodology were checked using certified reference material of human hair (BCR 397). Results: The mean concentrations of As, Cd, and Ni were found to be significantly higher in the scalp hair samples of cancerous patients as compared to referents, while reverse results were obtained in the case of Zn and Se (p < 0.01). Conclusions: The study revealed that low level of trace elements (Se, Zn) and high level of heavy elements (As, Cd, and Ni) were associated with increased risk of cancer. (C) 2014 Elsevier B.V. All rights reserved.
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