期刊
STROKE
卷 47, 期 7, 页码 1933-1935出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.116.012727
关键词
endovascular procedures; hypothermia; intra-arterial infusions; neuroprotection; reperfusion injury
资金
- National Science and Technology Supporting Plan [2011BAI08B07]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZY201309]
Background and Purpose-We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke. Methods-Patients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4 degrees C) in the ischemic territory through the angiographic catheter. Results-Twenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2 degrees C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3 degrees C). No obvious complications related to intra-arterial hypothermia were observed. Conclusions-Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.
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