Endovascular Hypothermia in Acute Ischemic Stroke Pilot Study of Selective Intra-Arterial Cold Saline Infusion

Background and Purpose-We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke. Methods-Patients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4 degrees C) in the ischemic territory through the angiographic catheter. Results-Twenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2 degrees C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3 degrees C). No obvious complications related to intra-arterial hypothermia were observed. Conclusions-Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.