期刊
STEROIDS
卷 109, 期 -, 页码 22-28出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2016.03.005
关键词
Multicomponent assembly; Spirooxindoles; Dihydropyridine; Cytotoxicity
资金
- Natural Science Foundation of China [21372206]
- Development Foundation of Priority, Ministry of Education [20134101130001]
Multicomponent assembly of steroidal dihydropyridinyl spirooxindoles from pregnenolone, isatins, malononitrile, and ammonium acetate is described, which involves the formation of two C-C bonds, two C-N bonds, and an all-carbon quaternary stereogenic center in a single operation. MIT assays showed that some of these compounds had moderate to excellent cytotoxicity against the tested cancer cell lines and were more potent than 5-FU. Particularly, compound 5o represented excellent inhibitory effect toward EC-109 (IC50 = 0.3 mu M), being about 33-fold more potent than 5-FU. (C) 2016 Elsevier Inc. All rights reserved.
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