期刊
STEROIDS
卷 115, 期 -, 页码 130-135出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2016.08.017
关键词
Litophyton mollis; 4 alpha-Methylated steroids; Structure elucidation; Cytotoxic activity
资金
- Greek State Scholarships Foundation
- AFR from the Fond National de la Recherche, Luxembourg [945920]
- Fondation de Recherche Cancer et Sang
- Recherches Scientifiques Luxembourg association
- Een Haerz fir kriibskrank Kanner association
- Action Lions Vaincre le Cancer association
- European Union [ITN RedCat 215009]
- Televie Luxembourg
- Research Institute of Pharmaceutical Sciences
- NRF/MEST of Republic of Korea [GCRC 2012-0001184]
- Brain Korea (BK21) PLUS program
Seven new (1-3, 5 and 8-10) and three previously reported (4, 6 and 7) 4 alpha-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5-8 exhibited cytotoxic activity against K562 human chronic myelogenous leukemia cells with IC50 values below 10 mu M, while at the same time displaying low toxicity against healthy PBMCs. (C) 2016 Elsevier Inc. All rights reserved.
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