期刊
STEM CELLS AND DEVELOPMENT
卷 25, 期 4, 页码 360-365出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/scd.2015.0195
关键词
-
资金
- Netherlands Institute for Regenerative Medicine (NIRM) [FES0908]
Zebrafish is gaining increased popularity as a model organism to study stem cell biology. It also is widely used as model system to visualize human leukemic stem cells. However, xenotransplantation of primary human stem/progenitor cells has not been described. Here, we use casper pigmentation mutant fish that are transparent crossed to fli-GFP transgenic fish as recipients of red labeled human CD34(+) cells. We have investigated various conditions and protocols with the aim to monitor and visualize the fate of transplanted human CD34(+) cells. We here report successful use of casper mutant zebrafish embryos for the direct monitoring of human hematopoietic stem cell transplantation, differentiation, and trafficking in vivo.
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