期刊
STEM CELL REVIEWS AND REPORTS
卷 12, 期 6, 页码 708-720出版社
SPRINGER
DOI: 10.1007/s12015-016-9682-4
关键词
Somatic cells; iPSCs; Reprogramming; Transdifferentiation; Histone modifications; Epigenetic; Cell fate conversion
资金
- National Nature Science Foundation of China [81230041, 81421064]
- National Basic Science and Development Program (973 Program) [2012CB518105]
Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.
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