期刊
STEM CELL REVIEWS AND REPORTS
卷 12, 期 6, 页码 621-633出版社
SPRINGER
DOI: 10.1007/s12015-016-9690-4
关键词
Mesenchymal stem cell; Autophagy; Stemness; Differentiation; Hypoxia; Acidity; Senescence
资金
- Italian Ministry of the Health
- Regione Emilia Romagna
Regulated self-consumption, also known as autophagy, is an evolutionary conserved process that degrades cellular components by directing them to the lysosomal compartment of eukaryotic cells. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining and remodeling cellular homeostasis during normal cellular and tissue development. Recent studies have demonstrated that autophagy is necessary for the maintenance of cellular stemness and for a number of differentiation processes, including the lineage determination of mesenchymal stem cells. These are multipotent progenitor cells with self-renewal capacities that can give rise to a subset of tissues and thus hold a consistent potential in regenerative medicine. Here, we review the current literature on the complex liaison between autophagy induced by various extra- or intracellular stimuli and the molecular targets that affect mesenchymal stem cells proliferation and differentiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据