期刊
STEM CELL RESEARCH
卷 16, 期 1, 页码 70-74出版社
ELSEVIER
DOI: 10.1016/j.scr.2015.12.008
关键词
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资金
- Danish National Advanced Technology Foundation [047-2011-1]
- European Union 7th Framework Program [PIAP-GA-2012-324451-STEMMAD]
- Novo Nordisk Fonden [NNF11OC1014514] Funding Source: researchfish
Skin fibroblasts were obtained from a 57-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a P301L mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.902C>T substitution in exon 10 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro. (C) 2015 Elsevier B.V.
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