期刊
STEM CELL RESEARCH
卷 16, 期 2, 页码 229-232出版社
ELSEVIER
DOI: 10.1016/j.scr.2016.01.002
关键词
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资金
- European Union [PIAP-GA-2012-324451-STEMMAD]
- Innovation Fund Denmark Brainstem [4108-00008B]
- UCPH Excellence Programme for Interdisciplinary Research
- Novo Nordisk Fonden [NNF11OC1014514] Funding Source: researchfish
Skin fibroblasts were obtained from a 48-year-old presymptomatic woman carrying a A79V mutation in the presenilin 1 gene (PSEN1), causing Alzheimer's disease (AD). Induced pluripotent stem cell (iPSCs) were derived via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF2, hL-MYC, hLIN28 and shTP53 genes. A79V-iPSCs were free of genomically integrated reprogramming genes, had the specific mutation but no additional genomic aberrancies, expressed the expected pluripotency markers and displayed in vitro differentiation potential to the three germ layers. The reported A79V-iPSCs line may be a useful resource for in vitro modeling of familial AD. (C) 2016 The Authors. Published by Elsevier B.V.
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