期刊
STATISTICS IN MEDICINE
卷 35, 期 21, 页码 3704-3716出版社
WILEY
DOI: 10.1002/sim.6958
关键词
treatment covariate interaction; clinical trial; meta-analysis; survival analysis
类别
资金
- Dana Funds
- International Breast Cancer Study Group (IBCSG) [CA-075362]
We have developed a method, called Meta-STEPP (subpopulation treatment effect pattern plot for meta-analysis), to explore treatment effect heterogeneity across covariate values in the meta-analysis setting for time-to-event data when the covariate of interest is continuous. Meta-STEPP forms overlapping subpopulations from individual patient data containing similar numbers of events with increasing covariate values, estimates subpopulation treatment effects using standard fixed-effects meta-analysis methodology, displays the estimated subpopulation treatment effect as a function of the covariate values, and provides a statistical test to detect possibly complex treatment-covariate interactions. Simulation studies show that this test has adequate type-I error rate recovery as well as power when reasonable window sizes are chosen. When applied to eight breast cancer trials, Meta-STEPP suggests that chemotherapy is less effective for tumors with high estrogen receptor expression compared with those with low expression. Copyright (c) 2016 John Wiley & Sons, Ltd.
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