期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 158, 期 -, 页码 1-8出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2016.01.011
关键词
Amphiphilic; Zinc phthalocyanine; Reactive oxygen species; CT-DNA; Photodynamic activity
类别
资金
- National Natural Science Foundation of China [21201102]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [13KJA150003, 12KJB150015]
beta-tetra (aminophenoxy) sulfonic substituted zinc phthalocyanines (SNZnPc), a novel amphiphilic zinc phthalocyanine (Pc), was synthesized. The photophysical, photochemical, and photobiology properties were studied. Results indicated that the synthesized SNZnPc has good amphiphilic property and high reactive oxygen species (ROSs) generation ability. Furthermore, SNZnPc has strong affinity to calf thymus DNA (CT-DNA) through intercalation ways and can effectively cleavage CT-DNA after irradiation by light with appropriate wavelength. (C) 2016 Elsevier B.V. All rights reserved.
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