期刊
SOFT MATTER
卷 12, 期 48, 页码 9786-9796出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sm01924b
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资金
- NSERC (Canada)
- Korea Institute of Science and Technology Information (KISTI)
- Basic Science Research Program [2015R1D1A1A09057469]
- KIAS (Korea Institute for Advanced Study)
In a crowded cellular interior, dissolved biomolecules or crowders exert excluded volume effects on other biomolecules, which in turn control various processes including protein aggregation and chromosome organization. As a result of these effects, a long chain molecule can be phase-separated into a condensed state, redistributing the surrounding crowders. Using computer simulations and a theoretical approach, we study the interrelationship between molecular crowding and chain organization. In a parameter space of biological relevance, the distributions of monomers and crowders follow a simple relationship: the sum of their volume fractions rescaled by their size remains constant. Beyond a physical picture of molecular crowding it offers, this finding explains a few key features of what has been known about chromosome organization in an E. coli cell.
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