期刊
SOFT MATERIALS
卷 14, 期 3, 页码 162-169出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/1539445X.2016.1172317
关键词
Controlled release; dextran; injectable hydrogels; poly(N-isopropylacrylamide); Thermosensitive
资金
- Ministry of National Education, CNCS - UEFISCDI [PN-II-ID-PCE-2012-4-0082]
Novel injectable thermosensitive hydrogel formulations with improved both water retention (WR) and drug release profile were prepared by adding dextran (DXT) to poly(N-isopropylacrylamide) (PNIPAM) aqueous solutions as a remedy against the demixing/syneresis phenomenon. The addition of the hydrophilic polysaccharide improved the WR of the hydrogel at 37 degrees C from about 12% in the absence of DXT to about 40-55% out of the initial amount introduced, depending on both PNIPAM and DXT concentrations. Also, the 5-fluorouracil release experiments showed an appreciably reduced burst effect for the DXT-containing hydrogels. The shape of the release profiles revealed the presence of two stages, differing each other from the point of view of the drug release rate.
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