期刊
SMALL
卷 12, 期 14, 页码 1920-1927出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201600243
关键词
colloidosomes; microcapsules; protocells
类别
资金
- ERC
- National Natural Science Foundation of China [41472310, 41130746]
- Chinese Ministry of Science and Technology [2014CB846003]
- China Scholarship Council
- EPSRC [EP/L002957/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/L002957/1] Funding Source: researchfish
An aqueous-based microcompartmentalized model involving the integration of partially hydrophobic Fe(III)-rich montmorillonite (FeM) clay particles as structural and catalytic building blocks for colloidosome membrane assembly, self-directed membrane remodeling, and signal-induced protocell communication is described. The clay colloidosomes exhibit size- and charge-selective permeability, and show dual catalytic functions involving spatially confined enzyme-mediated dephosphorylation and peroxidase-like membrane activity. The latter is used for the colloidosome-mediated synthesis and assembly of a temperature-responsive poly(N-isopropylacrylamide)(PNIPAM)/clay-integrated hybrid membrane. In situ PNIPAM elaboration of the membrane is coupled to a glucose oxidase (GOx)-mediated signaling pathway to establish a primitive model of chemical communication and functional activation within a synthetic protocell community comprising a mixed population of GOx-containing silica colloidosomes and alkaline phosphatase (ALP)-containing FeM-clay colloidosomes. Triggering the enzyme reaction in the silica colloidosomes gives a hydrogen peroxide signal that induces polymer wall formation in a coexistent population of the FeM-clay colloidosomes, which in turn generates self-regulated membrane-gated ALP-activity within the clay microcompartments. The emergence of new functionalities in inorganic colloidosomes via chemical communication between different protocell populations provides a first step toward the realization of interacting communities of synthetic functional microcompartments.
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