期刊
SMALL
卷 12, 期 27, 页码 3667-3676出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201503866
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资金
- Association pour la Recherche sur les Tumeurs de la Prostate
- Ligue Nationale Contre le Cancer
- Association Francaise contre les Myopathies
- CNRS
- INSERM
- PACA Canceropole
- INCa
- China Scholarship Council
- Ministry of Science and Technology of China [2012AA022501]
- Bourse d'Excellence Eiffel
- international ERA-Net EURONANOMED European Research project Target4Cancer
- ESTECO s.r.l. (Grant DDOS)
- University of Trieste (FRA project Combined Computational/Experimental Evidences for Multivalent Amphiphilic Nanoscale Carriers)
Self-assembly is a fundamental concept and a powerful approach in molecular science. However, creating functional materials with the desired properties through self-assembly remains challenging. In this work, through a combination of experimental and computational approaches, the self-assembly of small amphiphilic dendrons into nanosized supramolecular dendrimer micelles with a degree of structural definition similar to traditional covalent high-generation dendrimers is reported. It is demonstrated that, with the optimal balance of hydrophobicity and hydrophilicity, one of the self-assembled nanomicellar systems, totally devoid of toxic side effects, is able to deliver small interfering RNA and achieve effective gene silencing both in cells - including the highly refractory human hematopoietic CD34(+) stem cells - and in vivo, thus paving the way for future biomedical implementation. This work presents a case study of the concept of generating functional supramolecular dendrimers via self-assembly. The ability of carefully designed and gauged building blocks to assemble into supramolecular structures opens new perspectives on the design of self-assembling nanosystems for complex and functional applications.
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