期刊
SMALL
卷 12, 期 26, 页码 3550-3558出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201600616
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资金
- National Key Basic Research Program of the PRC [2014CB744501, 2014CB744504]
- Major International (Regional) Joint Research Program of China [81120108013]
- National Natural Science Foundation of China [81201175, 81530054, 81371611, 81471632, 81401469]
- Natural Science Foundation of Jiangsu Province [BK20130863]
- National Science Foundation for Post-doctoral Scientists of China [2013T60939, 2012M521934]
- Science Foundation of Nanjing University of Posts and Telecommunications [NY213045, NY214096]
The synthesis of mesoporous nanoparticles with controllable structure and organic groups is important for their applications. In this work, yolk-shell-structured periodic mesoporous organosilica (PMO) nanoparticles simultaneously incorporated with ethane-, thioether-, and benzene-bridged moieties are successfully synthesized. The preparation of the triple-hybridized PMOs is via a cetyltrimethylammonium bromide-directed sol-gel process using mixed bridged silsesquioxanes as precursors and a following hydrothermal treatment. The yolk-shell-structured triple-hybridized PMO nanoparticles have large surface area (320 m(2) g(-1)), ordered mesochannels (2.5 nm), large pore volume (0.59 cm(3) g(-1)), uniform and controllable diameter (88-380 nm), core size (22-110 nm), and shell thickness (13-45 nm). In vitro cytotoxicity, hemolysis assay, and histological studies demonstrate that the yolk-shell-structured triple-hybridized PMO nanoparticles have excellent biocompatibility. Moreover, the organic groups in the triple-hybridized PMOs endow them with an ability for covalent connection of near-infrared fluorescence dyes, a high hydrophobic drug loading capacity, and a glutathione-responsive drug release property, which make them promising candidates for applications in bioimaging and drug delivery.
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