期刊
SMALL
卷 12, 期 8, 页码 1072-1081出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201503188
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资金
- National Basic Research Program of China [2013CB933701, 2011CB91100]
- National Natural Science Foundation of China [21127901, 21402211, 81472186]
- Chinese Academy of Sciences [XDA09030308]
- Beijing Municipal Natural Science Foundation [7142122]
Collecting circulating tumor cells (CTCs) shed from solid tumor through a minimally invasive approach provides an opportunity to solve a long-standing oncology problem, the real-time monitoring of tumor state and analysis of tumor heterogeneity. However, efficient capture and detection of CTCs with diverse phenotypes is still challenging. In this work, a microfluidic assay is developed using the rationally-designed aptamer cocktails with synergistic effect. Enhanced and differential capture of CTCs for nonsmall cell lung cancer (NSCLC) patients is achieved. It is also demonstrated that the overall consideration of CTC counts obtained by multiple aptamer combinations can provide more comprehensive information in treatment monitoring.
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