期刊
SLEEP
卷 40, 期 1, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsw009
关键词
chronic variable sleep deficiency; neurobehavioral performance; subjective sleepiness; recovery sleep; physiological adaptation; recovery of function
资金
- Philips Lighting (Royal Philips Electronics, The Netherlands)
- National Space Biomedical Research Institute grants through NASA [NBPF02001, HPF00001, HPF01301, NCC 9-58]
- NHLBI training grant [T32-HL07901]
- NIH [R00 HL119618]
- Harvard Clinical and Translational Science Center from National Center for Research Resources [1 UL1RR025758-04]
Study Objectives: Intraindividual night-to-night sleep duration is often insufficient and variable. Here we report the effects of such chronic variable sleep deficiency on neurobehavioral performance and the ability of state-of-the-art models to predict these changes. Methods: Eight healthy males (mean age +/- SD: 23.9 +/- 2.4 years) studied at our inpatient intensive physiologic monitoring unit completed an 11-day protocol with a baseline 10-hour sleep opportunity and three cycles of two 3-hour time-in-bed (TIB) and one 10-hour TIB sleep opportunities. Participants received one of three polychromatic white light interventions (200 lux 4100K, 200 or 400 lux 17000K) for 3.5 hours on the morning following the second 3-hour TIB opportunity each cycle. Neurocognitive performance was assessed using the psychomotor vigilance test (PVT) administered every 1-2 hours. PVT data were compared to predictions of five group-average mathematical models that incorporate chronic sleep loss functions. Results: While PVT performance deteriorated cumulatively following each cycle of two 3-hour sleep opportunities, and improved following each 10-hour sleep opportunity, performance declined cumulatively throughout the protocol at a more accelerated rate than predicted by state-of-the-art group-average mathematical models. Subjective sleepiness did not reflect performance. The light interventions had minimal effect. Conclusions: Despite apparent recovery following each extended sleep opportunity, residual performance impairment remained and deteriorated rapidly when rechallenged with subsequent sleep loss. None of the group-average models were capable of predicting both the build-up in impairment and recovery profile of performance observed at the group or individual level, raising concerns regarding their use in real-world settings to predict performance and improve safety.
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