期刊
SHOCK
卷 45, 期 3, 页码 271-281出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SHK.0000000000000463
关键词
critical illness; mitochondria sepsis; Consensus
资金
- Astute Medical Inc.
- Baxter Healthcare Corporation
- Bellco S.R.L.
- Cytosorbents Inc.
- Fresenius Medical Care
- Spectral Diagnostics Inc.
- Toray Medical Co. Ltd.
- Wellcome Trust
- NIH [HL120877, HL074316, HL35440, HL122062, HL07820, NR013912, H L120877]
- Edwards Llifesciences
- Masimo
- Abbott
- Aethlon
- Alere
- Alung
- AM Pharma
- Astute Medical
- Atox Bio
- Baxter
- Cytosorbents
- venBio
- Gambro
- Grifols
- Roche
- Spectral Diagnostics
- Sangart
- Siemens
- Bard
- Kaneka
- Abbvie
- FAST Diagnostics
- EKF Diagnostics
- GE
- FMC
- ASAHI
- National Institute for Health Research [ACF-2007-21-020] Funding Source: researchfish
Mitochondria are an essential part of the cellular infrastructure, being the primary site for high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long-term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for intracellular injury and response to extrinsic stress have been a major focus of basic science and clinical research into the pathophysiology of acute illness. However, mitochondria have multiple metabolic and signaling functions that may be central in both the expression of sepsis and its ultimate outcome. In this review, the authors address five primary questions centered on the role of mitochondria in sepsis. This review should be used both as a summary source in placing mitochondrial physiology within the context of acute illness and as a focal point for addressing new research into diagnostic and treatment opportunities these insights provide.
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