期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 232, 期 -, 页码 514-522出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.03.169
关键词
Paper-based device; Acetaminophen; Electrochemical sensor; Carbon nanotube; Nanoparticle; Polyglutamic acid
资金
- Basic Science Research Program through National Research Foundation of Korea(NRF) - Ministry of Science, ICT & Future Planning [2008-0061891, 2013R1A1A2054887]
- National Research Foundation of Korea [2013R1A1A2054887] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In the present study, we constructed a functional paper fluidic device and evaluated its electrochemical performance by analyzing acetaminophen in the presence of ascorbic acid. The device was composed of a single-walled carbon nanotube (SWCNT) electrode and nafion-modified nitrocellulose membrane. Negatively-charged nafion was employed to build up a more negative charge on the nitrocellulose membrane, and gold nanoparticles and polyglutamic acid (AuNP-PGA) were deposited on the SWCNT electrode to enhance the electrochemical performance of the device. The device had a vertical flow format in which the sample solution flowed vertically through the paper. Using the nafion-modified nitrocellulose membrane and AuNP-PGAISWCNT film electrode as a component of the paper fluidic device, we obtained a distinguishable acetaminophen oxidation peak which was distinct from the ascorbic acid oxidation peak. The acetaminophen oxidation peak had a linear response with acetaminophen concentration, varying from 50 mu M to 300 mu M (r(2) = 0.992), which was broader than the standard drug dose range. The device exhibited a sensitivity of 13.3 mA/M and a detection limit of 15.0 mu M. The device was stable with a relative standard deviation of 3.3% (up to 2 weeks), and the reproducibility was 1.2-5.2%. Furthermore, the fabricated device accurately measured the amount of acetaminophen in pharmaceutical samples. (C) 2016 Elsevier B.V. All rights reserved.
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