期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 237, 期 -, 页码 924-934出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.06.169
关键词
Characterization; Interface; Nerve cuff electrode; Stimulating; Iridium oxide; PEDOT; Platinum black; Chronic
资金
- Happy Tech Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2009-0091918, 2010-0020786]
- KIST Institutional Program [2E26180]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2014R1A1A3052557]
- Ministry of Science, ICT & Future Planning, Republic of Korea [2E26180] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0091918] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nerve cuff electrodes for peripheral nerve prostheses require chronically implanted electrodes that simultaneously stimulate and record nerve activity. Particularly, the electrical stimulation that is provided should remain below the charge-carrying capacity of the electrode to avoid an irreversible reaction, electrode dissolution, and nerve damage. In this study, stimulating nerve cuff electrodes with Pt, IrOx, poly(3,4-ethylenedioxythiophene) (PEDOT), and platinum black (Pt black) on polyimide were fabricated, and their interface properties were compared for use as a stimulating electrode via in vitro and acute in vivo tests. The experimental results indicated that the stimulating nerve cuff electrodes with Pt black had the highest charge delivery capacity (62 times higher than Pt), the highest charge injection capacity (6 times higher than Pt), and the lowest interfacial impedance (2.9 times lower than Pt). After applying 60,000 biphasic pulses, the electrochemical and physical properties of the cuff electrode with Pt black were extremely well maintained. In addition, the cuff electrode with Pt black exhibited properly and safely transferred charge injection properties in the acute in vivo and preliminary long-term in vivo (15 weeks) test with minimizing nerve damage. As a result, stimulating nerve cuff electrode with Pt black is expected to be suitable for chronically implantable electrode, providing biocompatible and stable electrical stimulation. (C) 2016 Elsevier B.V. All rights reserved.
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