期刊
SEMINARS IN PERINATOLOGY
卷 40, 期 8, 页码 549-555出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semperi.2016.09.007
关键词
Neonatal hypoxic-ischemic; encephalopathy; therapeutic hypothermia; childhood outcomes; biomarkers
资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, United States [U10 HD27904, U10 HD21364, M01 RR80, U10 HD27853, M01 RR8084, U10 HD40492, M01 RR30, U10 HD27851, M01 RR39]
- [U10 HD27856]
- [M01 RR750]
- [U10 HD36790]
- [U10 HD27880]
- [M01 RR70]
- [U10 HD34216]
- [M01 RR32]
- [U10 HD40461]
- [U10 HD40521]
- [M01 RR44]
- [U10 HD21397]
- [M01 RR16587]
- [U10 HD40689]
- [M01 RR633]
- [U10 HD21373]
- [M01 RR2588]
- [U10 HD21385]
- [U10 HD27871]
- [M01 RR125]
- [UL1 RR24139]
In this article, we review the childhood outcomes of neonates with birth depression and/or hypoxic-ischemic encephalopathy. The outcomes of these children prior to the era of hypothermia for neuroprotection will first be summarized, followed by discussion of results from randomized controlled trials of therapeutic hypothermia for neonatal hypoxicischemic encephalopathy. The predictors of outcome in childhood following neonatal HIE using clinical and imaging biomarkers following hypothermia therapy will be described. (C) 2016 Elsevier Inc. All rights reserved.
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