期刊
SEMINARS IN NEPHROLOGY
卷 36, 期 3, 页码 139-152出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2016.03.002
关键词
Acute kidney injury; acute tubular necrosis; acute renal failure; ischemia reperfusion injury; regulated cell death; regulated necrosis
资金
- Netherlands Organization for Scientific Research [91712386]
- European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) [ALTF 69-2010]
- German Research foundation, Cluster of Excellence Inflammation at Interfaces [EXC306]
Necrosis is the predominant form of regulated cell death in acute kidney injury (AKI) and represents results in the formation of casts that appear in the urine sedimentation, referred to as muddy brown casts, which are part of the diagnosis of AKI. Pathologists referred to this typical feature as acute tubular necrosis. We are only beginning to understand the dynamics and the molecular pathways that underlie such typical necrotic morphology. In this review, we provide an overview of candidate pathways and summarize the emerging evidence for the relative contribution of these pathways of regulated necrosis, such as necroptosis, ferroptosis, mitochondrial permeability transition-mediated regulated necrosis, parthanatos, and pyroptosis. Inhibitors of each of these pathways are available, and clinical trials may be started after the detection of the most promising drug targets, which will be discussed here. With the global burden of AKI in mind, inhibitiors of regulated necrosis represent promising means to prevent this disease. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据