期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 39, 期 1, 页码 89-95出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-016-0603-z
关键词
IBD; Therapy; Cytokines; Immune response; Th9 cells; Il-9
资金
- DFG [WE4656/2-2, SFB 1181/B02]
- Clinical Research Unit [257]
Inflammatory bowel diseases are chronic, relapsing, immunologically mediated disorders of the gastrointestinal tract. Emerging evidence suggests a critical functional role of transcription factors and T cell-related cytokines in ulcerative colitis and Crohn's disease. Gut-residing T cells from patients with inflammatory bowel disease produce high amounts of IL-9. Experimental models of colitis highlighted that IL-9-producing T cells critically interfered with an intact barrier function of the intestinal epithelium by impacting cellular proliferation and tight junction molecules. The blockade of IL-9 was suited to significantly ameliorate the disease activity and severity in experimental models of inflammatory bowel disease thereby suggesting that targeting IL-9 might function as a novel targeted approach for therapy.
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