期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 38, 期 3, 页码 357-369出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-015-0525-1
关键词
TRP channels; Cancer; Tumour; Malignant transformation; Calciumregulation
资金
- INSERM
- la Ligue Nationale Contre le Cancer
- le Ministere de l'Education Nationale
- Region Nord/Pas-de-Calais
Transient receptor potential (TRP) channels are recently identified proteins that form a versatile family of ion channels, the majority of which are calcium permeable and exhibit complex regulatory patterns with sensitivity to multiple environmental factors. While this sensitivity has captured early attention, leading to recognition of TRP channels as environmental and chemical sensors, many later studies concentrated on the regulation of intracellular calcium by TRP channels. Due to mutations, dysregulation of ion channel gating or expression levels, normal spatiotemporal patterns of local Ca2+ distribution become distorted. This causes deregulation of downstream effectors sensitive to changes in Ca2+ homeostasis that, in turn, promotes pathophysiological cancer hallmarks, such as enhanced survival, proliferation and invasion. These observations give rise to the appreciation of the important contributions that TRP channels make to many cellular processes controlling cell fate and positioning these channels as important players in cancer regulation. This review discusses the accumulated scientific knowledge focused on TRP channel involvement in regulation of cell fate in various transformed tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据