期刊
SEMINARS IN IMMUNOLOGY
卷 28, 期 2, 页码 83-93出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2016.04.002
关键词
Neutrophil; Granulopoiesis; Epigenetic; Transcription factor; Cytokine
类别
资金
- Fondazione Cariplo (Giovani Ricercatori grant)
- European Research Council
- Ministero della salute, grant Ricerca Finalizzata
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG-15454]
- Fondazione Telethon
In addition to performing well-defined effector functions, neutrophils are now recognized as versatile and sophisticated cells with critical immunoregulatory roles. These include the release of a variety of proinflammatory or immunosuppressive cytokines, as well as the expression of genes with regulatory functions. Neutrophils share broad transcriptional features with monocytes, in keeping with the close developmental relation between the two cell types. However, neutrophil-specific gene expression patterns conferring cell type-specific responses to bacterial, viral or fungal components have been identified. Accumulating evidence suggest that these differences reflect the peculiar epigenomic and regulatory landscapes of neutrophils and monocytes, in turn controlled by the specific lineage-determining transcription factors shaping their identity. In this review, we will describe current knowledge on how neutrophil identity and function are controlled at the molecular level, focusing on transcriptional and chromatin regulation of neutrophil development and activation in response to inflammatory stimuli. (C) 2016 Elsevier Ltd. All rights reserved.
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