期刊
SEMINARS IN FETAL & NEONATAL MEDICINE
卷 21, 期 5, 页码 339-348出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2016.04.014
关键词
Cerebellum; Disruption; Prenatal; Magnetic resonance imaging; Neurodevelopment; Disability
类别
The vulnerability of the cerebellum during prenatal life to disruptive events such as hemorrhage and infection leads to a wide variety of morphological abnormalities. This review discusses various prenatal cerebellar disruptions including cerebellar agenesis, unilateral cerebellar hypoplasia, cerebellar cleft, global cerebellar hypoplasia, and vanishing cerebellum in Chiari type II malformation. For each entity, we discuss the definition, potential pathomechanism, clinical findings including neurocognitive and behavioral problems, neuroimaging features, and management. Accurate recognition of cerebellar disruptions and their differentiation from malformations is important in terms of diagnosis, prognosis, and genetic counselling. (C) 2016 Elsevier Ltd. All rights reserved.
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