期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 54, 期 -, 页码 20-27出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.09.002
关键词
Cancer cachexia; Muscle wasting; Experimental model; Preclinical; Translational
Cancer cachexia is a frequent syndrome that dramatically affects patient quality of life, anti-cancer treatment effectiveness, and overall survival. To date, no effective treatment is available and most of the studies are performed in experimental models in order to uncover the underlying mechanisms and to design prospective therapeutic strategies. This review summarizes the most relevant information regarding the use of animal models for studying cancer cachexia. Technical limitations and degree of recapitulation of the features of human cachexia are highlighted, in order to help investigators choose the most suitable model according to study-specific endpoints. (C) 2015 Elsevier Ltd. All rights reserved.
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