期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 54, 期 -, 页码 165-176出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.02.025
关键词
Topoisomerase; Meiosis; Recombination; Double strand break; SPO11
资金
- Labex Saclay Plant Sciences-SPS [ANR-10-LABX-0040-SPS]
- Centre National pour la Recherche Scientifique (CNRS)
- European Research Council Executive Agency under the European Community's Seventh Framework Programme (FP7) [322788]
- European Research Council (ERC) [322788] Funding Source: European Research Council (ERC)
Meiotic recombination is initiated by the formation of programmed DNA double-strand breaks (DSBs). More than 15 years ago, Spo11 was identified as the protein responsible for meiotic DSB formation, notably because of its striking similarities with the A subunit of topoisomerase VI (TopoVI). TopoVI are enzymes that modify DNA topology by generating transient DSBs and are active as heterotetramers, composed of two A and two B subunits. A(2) dimers catalyse the DNA cleavage reaction, whereas the B subunits regulate A(2) conformation, DNA capture, cleavage and re-ligation. The recent identification in plants and mammals of a B-like TopoVI subunit that interacts with SPO11 and is required for meiotic DSB formation makes us to reconsider our understanding of the meiotic DSB catalytic complex. We provide here an overview of the knowledge on TopoVI structure and mode of action and we compare them with their meiotic counterparts. This allows us to discuss the nature, structure and functions of the meiotic TopoVI-like complex during meiotic DSB formation. (C) 2016 Elsevier Ltd. All rights reserved.
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