期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 59, 期 -, 页码 2-9出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.06.010
关键词
Phosphatidylinositol phosphate; Spermatogenesis; Spermiogenesis; Male germ cell; Mice; Flies
资金
- Canadian Institutes of Heath Research (CIHR MOP) [130437]
Phosphatidylinositol phosphates (PIPs)(1) are membrane lipids with crucial roles during cell morphogenesis, including the establishment of cytoskeletal organization, membrane trafficking, cell polarity, cell- cycle control and signaling. Recent studies in mice (Mus musculus), fruit flies (Drosophila melanogaster) and other organisms have defined germ cell intrinsic requirements for these lipids and their regulatory enzymes in multiple aspects of sperm development. In particular, PIP levels are crucial in germline stem cell maintenance, spermatogonial proliferation and survival, spermatocyte cytokinesis, spermatid polarization, sperm tail formation, nuclear shaping, and production of mature, motile sperm. Here, we briefly review the stages of spermatogenesis and discuss the roles of PIPs and their regulatory enzymes in male germ cell development. (C) 2016 Elsevier Ltd. All rights reserved.
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