期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 56, 期 -, 页码 58-70出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.01.029
关键词
X chromosome inactivation; Xist; Chromatin; Non-coding RNA; Epigenetic
Chromosome silencing by Xist RNA occurs in two steps; localisation in cis within the nuclear matrix to form a domain that corresponds to the territory of the inactive X chromosome elect, and transduction of silencing signals from Xist RNA to the underlying chromatin. Key factors that mediate these processes have been identified in a series of recent studies that harnessed comprehensive proteomic or genetic screening strategies. In this review we discuss these findings in light of prior knowledge both of Xist-mediated silencing and known functions/properties of the novel factors. (C) 2016 Elsevier Ltd. All rights reserved.
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