期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 59, 期 -, 页码 110-117出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.06.013
关键词
LncRNA; RNA binding proteins; Spermatogenesis; Conservation; Noncoding RNA; Evolution of reproduction
资金
- National Basic Research Program of China [2015CB943002, 2013CB945201]
- Natural Science Foundation [81270737]
- Jiangsu Innovation and Entrepreneurship Program
Spermatogenesis is one of the fundamental processes of sexual reproduction, present in almost all metazoan animals. Like many other reproductive traits, developmental features and traits of spermatogenesis are under strong selective pressure to change, both at morphological and underlying molecular levels. Yet evidence suggests that some fundamental features of spermatogenesis may be ancient and conserved among metazoan species. Identifying the underlying conserved molecular mechanisms could reveal core components of metazoan spermatogenic machinery and provide novel insight into causes of human infertility. Conserved RNA-binding proteins and their interacting RNA network emerge to be a common theme important for animal sperm development. We review research on the recent addition to the RNA family - Long non-coding RNA (lncRNA) and its roles in spermatogenesis in the context of the expanding RNA-protein network. (C) 2016 Elsevier Ltd. All rights reserved.
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