期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 53, 期 -, 页码 85-93出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.09.021
关键词
FGF21; FGF15; FGF19; FGF1; Obesity; Metabolism
资金
- American Diabetes Association Junior Faculty Award [7-13-JF-49]
- National Institutes of Health (NIH) [R01DK106104, F32DK102347]
The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions. (C) 2015 Elsevier Ltd. All rights reserved.
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