期刊
CIRCULATION RESEARCH
卷 116, 期 11, 页码 1783-1799出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.305432
关键词
mitochondria; mitochondrial degradation; mitochondrial dynamics; protein kinase C; reactive oxygen species
资金
- National Institutes of Health [HL52141, NIAAA11147]
- Smith Stanford Graduate Fellowship
Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
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