期刊
CIRCULATION RESEARCH
卷 116, 期 2, 页码 235-236出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.114.305490
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资金
- NHLBI NIH HHS [HL122737, R01 HL123295, R01 HL114437, R01 HL122737, HL114437, R01 HL103205, HL103205] Funding Source: Medline
Myheart is a cardiac-specific long-noncoding (lnc) RNA with targeted modulation of chromatin-modifying switching-defective/sucrose-nonfermenting complex via direct interaction with Brg1. Genetic induction of Myheart in mouse heart has a significant protective effect against the pathogenesis of heart failure. LncRNAs are emerging epigenetic regulators with potentially important roles in cardiac development and diseases.
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