期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 8, 期 343, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aad7121
关键词
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资金
- NIH [R01 DK090989]
- Public Health Service Institutional Research Training Award [T32 AI007180]
- Diane Belfer Program for Human Microbial Ecology
- Daniel and Leslie Ziff Fund
- C D fund
Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disruptmicrobiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered a-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
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