期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 571, 期 -, 页码 955-962出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2016.07.082
关键词
Free fatty acids (FFAs); M. galloprovincialis; NanoLC-EI-MS; Biomonitoring; Bioindicator; Environmental pollution
资金
- National Interest Research Project (PRIN) [Prot. 2010ARBLT7_001/008]
The present work aims to elucidate the free fatty acid (FFA) profile of the mussel Mytilus galloprovincialis caged in an anthropogenically impacted area and in a reference site through an innovative and validated analytical approach for the assessment of biological alterations induced by marine pollution. The FFA pattern is involved in the regulation of different cellular pathways and differs with respect to metabolic stimuli. To this purpose, the lipid fraction of mussels coming from both sampling areas was extracted and the FFA fractions were isolated and purified by a solid phase extraction; then, nano-scale liquid chromatography coupled to electron ionization mass spectrometry (nanoLC-EI-MS) was employed for the characterization of the two samples. A total of 19 and 17 FFAs were reliably identified in the mussels coming from the reference and polluted site, respectively. Significant qualitative and quantitative differences found in saturated, monounsaturated and polyunsaturated species may be exploited as typical pollution biomarkers (e.g, alteration of the fatty acid biosynthetic system and lipotoxicity) and explain adverse and compromising effects (e.g. oxidative stress and inflammatory processes) related to environmental pollution. (C) 2016 Elsevier B.V. All rights reserved.
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