期刊
SCIENCE CHINA-LIFE SCIENCES
卷 59, 期 9, 页码 950-957出版社
SCIENCE PRESS
DOI: 10.1007/s11427-016-0114-9
关键词
induced pluripotent stem cell; multiple sclerosis; neural stem cell; regenerative medicine; transplantation
类别
资金
- China National Basic Research Program [2013CB966901, 2012CBA01303]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01040108]
- National Thousand Young Talents Program
- National Natural Science Foundation of China [31271592, 31570995, 31400831]
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell (NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells (iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis (EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据