期刊
SCIENCE CHINA-CHEMISTRY
卷 59, 期 6, 页码 765-769出版社
SCIENCE PRESS
DOI: 10.1007/s11426-016-5572-5
关键词
DNA; gold nanoparticles; single nucleotide polymorphisms (SNP); surface plasmon resonance; sensing
资金
- National Basic Research Program of China [2013CB932803]
- National Natural Science Foundation of China [91427302, 21421064]
- National Natural Science Foundation of China-Deutsche Forschungsgemeinschaft (NSFC-DFG) [TRR61]
DNA modified nanoparticles (AuNPs) are an established and widely used type of nucleotide sensor. We sought to improve the design by applying short rigid DNA duplexes near the surface of the AuNPs forming a so called double-anchored AuNP sensor, and compared it with other conventional DNA modified AuNPs. The improved design exhibited higher assembly efficiency, and consequently increased its sensitivity to target DNA.
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