期刊
SCIENCE
卷 354, 期 6314, 页码 893-897出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aah5454
关键词
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资金
- Federation pour la Recherche sur le Cerveau
- Region Ile-de-France DIM NeRF
- France-BioImaging
- Centre National de la Recherche Scientifique
- Ecole Normale Superieure
- Institut National de la Sante et de la Recherche Medicale
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV4-0007-01]
- Fondation pour la Recherche Medicale (FRM) award [DEq. 2000326472]
- Investissements d'Avenir program of the French government by the ANR [ANR-10-LABX-54 MEMO LIFE, ANR-11-IDEX-0001-02]
- French Ministry of Higher Education and Research
- FRM award [FDT20160435297]
- European Research Council [293544]
- Wellcome [100269/Z/12/Z]
- Wellcome Trust [100269/Z/12/Z] Funding Source: Wellcome Trust
- MRC [G0800575] Funding Source: UKRI
- Medical Research Council [G0800575] Funding Source: researchfish
- Wellcome Trust [100269/Z/12/Z] Funding Source: researchfish
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV4-0007] Funding Source: Agence Nationale de la Recherche (ANR)
A kinship between cranial and pelvic visceral nerves of vertebrates has been accepted for a century. Accordingly, sacral preganglionic neurons are considered parasympathetic, as are their targets in the pelvic ganglia that prominently control rectal, bladder, and genital functions. Here, we uncover 15 phenotypic and ontogenetic features that distinguish pre- and postganglionic neurons of the cranial parasympathetic outflow from those of the thoracolumbar sympathetic outflow in mice. By every single one, the sacral outflow is indistinguishable from the thoracolumbar outflow. Thus, the parasympathetic nervous system receives input from cranial nerves exclusively and the sympathetic nervous system from spinal nerves, thoracic to sacral inclusively. This simplified, bipartite architecture offers a new framework to understand pelvic neurophysiology as well as development and evolution of the autonomic nervous system.
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