期刊
SCIENCE
卷 353, 期 6297, 页码 380-382出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf3951
关键词
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资金
- NIH [R01 AI091595, R37 AI050529, R01 AI120810, P30 AI045008, R01 GM101209]
- NSF [2011119472]
- Agence Nationale de Recherche sur le Sida [ANRS 12125/12182/12255/12325]
- Jane Goodall Institute
- Arthur L. Greene Fund
- Harvard University
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1457260] Funding Source: National Science Foundation
The evolutionary origins of the bacterial lineages that populate the human gut are unknown. Here we show that multiple lineages of the predominant bacterial taxa in the gut arose via cospeciation with humans, chimpanzees, bonobos, and gorillas over the past 15 million years. Analyses of strain-level bacterial diversity within hominid gut microbiomes revealed that clades of Bacteroidaceae and Bifidobacteriaceae have been maintained exclusively within host lineages across hundreds of thousands of host generations. Divergence times of these cospeciating gut bacteria are congruent with those of hominids, indicating that nuclear, mitochondrial, and gut bacterial genomes diversified in concert during hominid evolution. This study identifies human gut bacteria descended from ancient symbionts that speciated simultaneously with humans and the African apes.
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