期刊
SCIENCE
卷 353, 期 6306, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf1420
关键词
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资金
- National Institutes of Health [R01HG005853, R01HG005084, R01GM104975]
- Canadian Institutes of Health Research [FDN-143264, FDN-143265, FDN143301]
- RIKEN Strategic Programs for RD
- JSPS Kakenhi [15H04483]
- National Science Foundation [DBI\0953881, MCB\1244043, NSF 00039202]
- European Research Council (ERC) Advanced Investigator Grant [AdG-294542]
- ERC Advanced Grant (European Commission)
- Ministry of Education, Culture, Sports, Sciences and Technology, MEXT [15H04402]
- Genome Canada Genome Innovation network (through the Ontario Genomics Institute)
- Ontario Genomics Institute
- Canadian Cystic Fibrosis Foundation
- Canadian Cancer Society
- Pancreatic Cancer Canada
- University Health Network
- Cyber-Enabled Discover and Innovation (CDI) [OIA-1028394]
- ERC Starting Independent Researcher Grant [278212]
- ARRS project [J1-5424]
- Serbian Ministry of Education and Science [11144006]
- National Natural Science Foundation of China
- RIKEN Foreign Postdoctoral Researcher Program
- U. of Minnesota Doctoral Dissertation Fellowship
- European Research Council (ERC) [278212] Funding Source: European Research Council (ERC)
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0953881] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1244043] Funding Source: National Science Foundation
- Office of Integrative Activities
- Office Of The Director [1028394] Funding Source: National Science Foundation
- Grants-in-Aid for Scientific Research [15H04483] Funding Source: KAKEN
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments. Negative interactions connected functionally related genes, mapped core bioprocesses, and identified pleiotropic genes, whereas positive interactions often mapped general regulatory connections among gene pairs, rather than shared functionality. The global network illustrates how coherent sets of genetic interactions connect protein complex and pathway modules to map a functional wiring diagram of the cell.
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