期刊
SCIENCE
卷 351, 期 6275, 页码 849-854出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aab3103
关键词
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资金
- Canadian Institutes of Health Research [FDN 143337, MOP 126137/NIA 288936, MOP 111152/MOP 123390]
- Natural Sciences and Engineering Research Council of Canada [DG 418546-2, 4080442011]
- Canada Research Chairs Program
- Brain Canada/W. Garfield Weston Foundation
- James McGill Chair Program
- Canadian Foundation for Innovation [LOF 28331]
- Research Institute of the McGill University Health Centre
- Vanier fellowship
- Biotechnology and Biological Sciences Research Council [1068928] Funding Source: researchfish
- Medical Research Council [G0700188] Funding Source: researchfish
- MRC [G0700188] Funding Source: UKRI
Astrocytes are specialized and heterogeneous cells that contribute to central nervous system function and homeostasis. However, the mechanisms that create and maintain differences among astrocytes and allow them to fulfill particular physiological roles remain poorly defined. We reveal that neurons actively determine the features of astrocytes in the healthy adult brain and define a role for neuron-derived sonic hedgehog (Shh) in regulating the molecular and functional profile of astrocytes. Thus, the molecular and physiological program of astrocytes is not hardwired during development but, rather, depends on cues from neurons that drive and sustain their specialized properties.
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