期刊
SCIENCE
卷 354, 期 6311, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf3928
关键词
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资金
- NIGMS Postdoctoral Research Associate Program fellowship
- AIDS research fellowship from the NIH Office of AIDS Research
- NIH Intramural AIDS Targeted Antiviral Program
- National Key Research Program of China [2016YFA0500200]
- HHMI
- Intramural Research Program of NINDS
- Intramural Research Program of NICHD
- UCL School of Pharmacy PhD studentship
- MRC [MR/M00676X/1] Funding Source: UKRI
The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle that plays crucial roles in numerous cellular functions. We used emerging superresolution imaging technologies to clarify the morphology and dynamics of the peripheral ER, which contacts and modulates most other intracellular organelles. Peripheral components of the ER have classically been described as comprising both tubules and flat sheets. We show that this system consists almost exclusively of tubules at varying densities, including structures that we term ER matrices. Conventional optical imaging technologies had led to misidentification of these structures as sheets because of the dense clustering of tubular junctions and a previously uncharacterized rapid form of ER motion. The existence of ER matrices explains previous confounding evidence that had indicated the occurrence of ER sheet proliferation after overexpression of tubular junction-forming proteins.
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