期刊
SCIENCE
卷 353, 期 6303, 页码 1023-1027出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf4434
关键词
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资金
- Scripps Research Institute
- NIH (National Institute of General Medical Sciences) [2R01GM084019]
- Shanghai Institute of Organic Chemistry
- Zhejiang Medicine
- Pharmaron
- Deutsche Forschungsgemeinschaft
- NSF Center for Chemical Innovation: Center for Selective C-H Functionalization [CHE-1205646]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1205646] Funding Source: National Science Foundation
Morphogenetic signals control the patterning of multicellular organisms. Cytokinins are mobile signals that are perceived by subsets of plant cells. We found that the responses to cytokinin signaling during Arabidopsis development are constrained by the transporter PURINE PERMEASE 14 (PUP14). In our experiments, the expression of PUP14 was inversely correlated to the cytokinin signaling readout. Loss of PUP14 function allowed ectopic cytokinin signaling accompanied by aberrant morphogenesis in embryos, roots, and the shoot apical meristem. PUP14 protein localized to the plasma membrane and imported bioactive cytokinins, thus depleting apoplastic cytokinin pools and inhibiting perception by plasma membrane-localized cytokinin sensors to create a sink for active ligands. We propose that the spatiotemporal cytokinin sink patterns established by PUP14 determine the cytokinin signaling landscape that shapes the morphogenesis of land plants.
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