期刊
SCIENCE
卷 353, 期 6304, 页码 1129-1132出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aah6157
关键词
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资金
- U.S. Military Research and Materiel Command
- U.S. Military HIV Research Program
- Henry M. Jackson Foundation [W81XWH-11-2-0174]
- National Institutes of Health [AI095985, AI096040, AI100663, AI124377]
- Ragon Institute of MGH
- MIT
- Harvard
- Sao Paulo Research Foundation (FAPESP) [2011/18703-2, 2014/17766-9]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/18703-2] Funding Source: FAPESP
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans.
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