期刊
SCIENCE
卷 354, 期 6317, 页码 1265-1269出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aai8611
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资金
- National Institutes of Health (National Institute of General Medical Sciences) [R01-GM62871]
- Alexander von Humboldt Foundation
- German National Merit Foundation
- David S. Koons SURF (Summer Undergraduate Research Fellowship) Endowment
- Gordon and Betty Moore Foundation (for the Caltech Center for Catalysis and Chemical Synthesis)
Alkylboron compounds are an important family of target molecules, serving as useful intermediates, as well as end points, in fields such as pharmaceutical science and organic chemistry. Facile transformation of carbon-boron bonds into a wide variety of carbon-X bonds (where X is, for example, carbon, nitrogen, oxygen, or a halogen), with stereochemical fidelity, renders the generation of enantioenriched alkylboronate esters a powerful tool in synthesis. Here we report the use of a chiral nickel catalyst to achieve stereoconvergent alkyl-alkyl couplings of readily available racemic alpha-haloboronates with organozinc reagents under mild conditions. We demonstrate that this method provides straightforward access to a diverse array of enantioenriched alkylboronate esters, in which boron is bound to a stereogenic carbon, and we highlight the utility of these compounds in synthesis.
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