期刊
SCIENCE
卷 353, 期 6298, 页码 492-495出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf7501
关键词
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资金
- Stiftelsen JC Kempes Minnes Stipendiefond
- EMBO grant [ALTF 1629-2011]
- Swedish Research Council [2015-02874, 2011-4937, K2014-56X-11222-20-5]
- Carl Tryggers Stiftelse for Naturvetenskaplig Forskning
- German Center for Infection Research
- Swedish Research Council [2015-02874] Funding Source: Swedish Research Council
Pathogenic bacteria have evolved numerous virulence mechanisms that are essential for establishing infections. The enterobacterium Yersinia uses a type III secretion system (T3SS) encoded by a 70-kilobase, low-copy, IncFII-class virulence plasmid. We report a novel virulence strategy in Y. pseudotuberculosis in which this pathogen up-regulates the plasmid copy number during infection. We found that an increased dose of plasmid-encoded genes is indispensable for virulence and substantially elevates the expression and function of the T3SS. Remarkably, we observed direct, tight coupling between plasmid replication and T3SS function. This regulatory pathway provides a framework for further exploration of the environmental sensing mechanisms of pathogenic bacteria.
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