期刊
SCIENCE
卷 352, 期 6288, 页码 990-993出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad5937
关键词
-
资金
- U.S. NIH [R01 GM046383, P50 GM107615]
- National Research Foundation of Korea [NRF-2011-357-C00151, 2012M3A9B9036680]
Negative cooperativity is a phenomenon in which the binding of one or more molecules of a ligand to a multimeric receptor makes it more difficult for subsequent ligand molecules to bind. Negative cooperativity can make a multimeric receptor's response more graded than it would otherwise be. However, through theory and experimental results, we show that if the ligand binds the receptor with high affinity and can be appreciably depleted by receptor binding, then negative cooperativity produces a qualitatively different type of response: a highly ultrasensitive response with a pronounced threshold. Because ultrasensitivity and thresholds are important for generating various complex systems-level behaviors, including bistability and oscillations, negative cooperativity may be an important ingredient in many types of biological responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据